Brigitte C. Kaufmann, PhD

Project Manager SNF Ambizione
T +41 41 229 54 49
brigitte.kaufmann@unilu.ch
Frohburgstrasse 3, Room 1.B14
CV
Brigitte C. Kaufmann studied psychology at the Universities of Freiburg and Bern, focusing on clinical psychology and neuropsychology. She then completed her PhD at the Graduate School for Health Sciences at the University of Bern. In her dissertation, she investigated the neural mechanisms underlying a common post‑stroke visuospatial attention deficit: horizontal neglect. Six out of ten right-hemispheric stroke patients show a horizontal neglect and perceive the left side of their environment only to a limited extent. In everyday life this can lead to difficulties such as reading, navigating, or avoiding obstacles.
After completing her PhD, she worked as a postdoctoral researcher at the Paris Brain Institute (ICM) with an SNSF Early Postdoc.Mobility fellowship. There, she broadened her expertise in cognitive neuroscience and expanded her methodological skills, particularly in neuroimaging techniques.
Since March 2026, she has been working at the Faculty of Behavioral Sciences and Psychology at the University of Lucerne. She leads the Ambizione project funded by the Swiss National Science Foundation, “VERA – Unravelling Vertical Visuospatial Attention to Enhance Post-Stroke Recovery.” While the horizontal dimension of neglect has already been well studied, the vertical dimension of visuospatial attention—orientation upward and downward—has received little research attention, even though it plays a central role in everyday life, for example in recognizing traffic lights, scanning shelves, or climbing stairs. The project combines eye‑movement analyses, magnetic resonance imaging, and non‑invasive brain stimulation to systematically investigate vertical visuospatial attention, its neural correlates, and its relevance for post‑stroke rehabilitation.
Publications
- Kaufmann, B. C., Nyffeler, T., Geiser, N., Nef, T., & Cazzoli, D. (2025). Auditory motion stimulation as an add-on therapeutical approach is feasible, enjoyable, and associated with a significant improvement of neglect outcome: A non-randomized, controlled group-matched study. Neuropsychological Rehabilitation. https://doi.org/10.1080/09602011.2025.2476068
- Nyffeler, T., Kaufmann, B. C., Rühe, H., Geiser, N., & Cazzoli, D. (2025). Incidence of Visuospatial Neglect in Acute Stroke: Assessment and Stroke Characteristics in an Unselected 1-Year Cohort. Stroke. https://doi.org/10.1161/STROKEAHA.124.048907
- Kaufmann, B. C. (2025). Low-dimensional controllability of brain networks. PLOS Computational Biology. https://doi.org/10.1371/journal.pcbi.1012691
- Dampfhoffer, A., Kaufmann, B. C., Nyffeler, T., & Cazzoli, D. (2025). Neglect after isolated thalamic stroke: a systematic review of the literature. Cerebrovascular Diseases, 1–27. https://doi.org/10.1159/000545473
- Cazzoli, D., Kaufmann, B. C., Nyffeler, T., Nef, T., Geiser, N., Angelva, N. E., … Single, M. (2025). Smartphone-Based Auditory Motion Stimulation for Hemispatial Neglect: Development and Usability Study (Preprint). Journal of Medical Internet Research. https://doi.org/10.2196/preprints.82442
- Kaufmann, B. C. (2025). Unveiling spatial and non-spatial aspects of neglect in everyday behavior. Cortex. https://doi.org/10.1016/j.cortex.2024.10.002
- Cazzoli, D., Kaufmann, B. C., & Nyffeler, T. (2024). Comparison of uni- and multimodal motion stimulation on visual neglect: A proof-of-concept study. Cortex, 171, 194-203 ff. https://doi.org/10.1016/j.cortex.2023.10.018
- Kaufmann, B. C. (2024). Intracortical recordings reveal vision-to-action cortical gradients driving human exogenous attention. Nature communications. https://doi.org/doi.org/10.1038/s41467-024-46013-4
- Kaufmann, B. C. (2024). Listening to classical music influences brain connectivity in post-stroke aphasia: a pilot study. Annals of Physical and Rehabilitation Medicine. https://doi.org/https://doi.org/10.1016/j.rehab.2024.101825
- Cazzoli, D., Kaufmann, B. C., Pastore-Wapp, M., & Nyffeler, T. (2024). Severity-dependent interhemispheric white matter connectivity predicts post-stroke neglect recovery. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.1311-23.2024
- Kaufmann, B. C., & Camenzind, M. (2024). The phenomenology of pareidolia in healthy subjects and patients with left- or right-hemispheric stroke. Heliyon. https://doi.org/10.1016/J.HELIYON.2024.E27414
- Kaufmann, B., Nyffeler, T., & Cazzoli, D. (2024). Vertical neglect towards the lower space after bilateral parietal strokes – A case study. Cortex. https://doi.org/10.1016/j.cortex.2024.10.012
- Cazzoli, D., Kaufmann, B. C., & Nyffeler, T. (2023). A case study of left visual neglect after right pontine lesion: pathophysiological evidence for the infratentorial involvement in human visual attention. Journal of Neurophysiology, 129 (6), 1534-1539 ff. https://doi.org/10.1152/jn.00123.2023
- Cazzoli, D., Kaufmann, B. C., Pastore-Wapp, M., & Nyffeler, T. (2023). Joint impact on attention, alertness and inhibition of lesions at a frontal white matter crossroad. Brain, 146 (4), 1467-1482 ff. https://doi.org/10.1093/brain/awac359
- Cazzoli, D., Kaufmann, B. C., & Nyffeler, T. (2023). Causal evidence for the multiple-demand brain network: it takes three to tango. Brain, 146 (12), e115-e116 ff. https://doi.org/10.1093/brain/awad217
- Pastore-Wapp, M., Kaufmann, B. C., Nyffeler, T., & Bohlhalter, S. (2023). Feasibility of a combined intermittent theta-burst stimulation and video game-based dexterity training in Parkinson’s disease. Journal of NeuroEngineering and Rehabilitation, 20 (1). https://doi.org/10.1186/s12984-023-01123-w
- Geiser, N., Maaijwee, N., Cazzoli, D., Nef, T., Rühe, H., Nyffeler, T., & Kaufmann, B. C. (2022). Visual Neglect after PICA Stroke-A Case Study. Brain sciences, 12 (2), 290 ff. https://doi.org/10.3390/brainsci12020290
- Kaufmann, B. C., Geiser, N., Nyffeler, T., & Cazzoli, D. (2022). Effects of Virtual Reality–Based Multimodal Audio-Tactile Cueing in Patients With Spatial Attention Deficits: Pilot Usability Study. JMIR Serious Games, 2 (10), e34884 ff. https://doi.org/10.2196/34884
- Cazzoli, D., Nyffeler, T., & Kaufmann, B. C. (2022). Auditory spatial cueing reduces neglect after right-hemispheric stroke: A proof of concept study. Cortex, 148, 152-167 ff. https://doi.org/10.1016/j.cortex.2021.12.009
- Kaufmann, B. C. (2022). Response to the Letter by Schenke et al. on ‘Auditory spatial cueing reduces neglect after righthemispheric stroke: A proof of concept study’ by Kaufmann et al., 2022. Cortex. https://doi.org/10.1016/J.CORTEX.2022.09.009
- Kaufmann, B. C. (2022). The connectional anatomy of visual mental imagery: evidence from a patient with left occipito-temporal damage. Brain Structure and Function. https://doi.org/doi.org/10.1007/s00429-022-02505-x
- Cazzoli, D., Nyffeler, T., & Kaufmann, B. C. (2021). Development of a Search Task Using Immersive Virtual Reality: Proof-of-Concept Study. JMIR Serious Games; JMIR, 9 (3), e29182 ff. https://doi.org/10.2196/29182
- Cazzoli, D., Nyffeler, T., & Kaufmann, B. C. (2021). Visual Neglect After an Isolated Lesion of the Superior Colliculus. JAMA Neurology, 78 (12), 1531 ff. https://doi.org/10.1001/jamaneurol.2021.3863
- Cazzoli, D., Kaufmann, B. C., & Nyffeler, T. (2021). Anterior insula and inferior frontal gyrus: where ventral and dorsal visual attention systems meet. Brain Communications, 1, fcaa220 ff. https://doi.org/10.1093/braincomms/fcaa220
- Nef, T., Müri, R. M., Koenig-Bruhin, M., Cazzoli, D., Kaufmann, B. C., & Nyffeler, T. (2021). Video-Oculography During Free Visual Exploration to Detect Right Spatial Neglect in Left-Hemispheric Stroke Patients With Aphasia: A Feasibility Study. Frontiers in Neuroscience, 15, 640049 ff. https://doi.org/10.3389/fnins.2021.640049
- Cazzoli, D., Kaufmann, B. C., Pflugshaupt, T., Bohlhalter, S., & Nyffeler, T. (2020). Eyetracking during free visual exploration detects neglect more reliably than paper-pencil tests. Cortex, 223–235. https://doi.org/10.1016/j.cortex.2020.04.021
- Cazzoli, D., Kaufmann, B. C., & Nyffeler, T. (2020). Immersive 3D Virtual Reality Cancellation Task for Visual Neglect Assessment: A Pilot Study. Frontiers in Human Neuroscience, 180 ff. https://doi.org/10.3389/fnhum.2020.00180
- Cazzoli, D., Kaufmann, B. C., & Nyffeler, T. (2020). Test-Retest-Reliability of Video-Oculography During Free Visual Exploration in Right-Hemispheric Stroke Patients With Neglect. Frontiers in Neuroscience, 731 ff. https://doi.org/10.3389/fnins.2020.00731
- Kaufmann, B. C. (2020). The right anterior temporal lobe critically contributes to magnitude knowledge. Brain Communications. https://doi.org/10.1093/BRAINCOMMS/FCAA157
- Cazzoli, D., Kaufmann, B. C., & Nyffeler, T. (2020). Visual Exploration Area in Neglect: A New Analysis Method for Video-Oculography Data Based on Foveal Vision. Frontiers in Neuroscience. https://doi.org/10.3389/FNINS.2019.01412
- Cazzoli, D., Kaufmann, B. C., & Nyffeler, T. (2019). Re‐fixation and perseveration patterns in neglect patients during free visual exploration. European Journal of Neuroscience, 10, 1244–1253. https://doi.org/10.1111/ejn.14309
- Cazzoli, D., Nyffeler, T., Kaufmann, B. C., Pflugshaupt, T., & Bohlhalter, S. (2019). Theta burst stimulation in neglect after stroke: functional outcome and response variability origins. Brain, 4, 992–1008. https://doi.org/10.1093/brain/awz029
- Cazzoli, D., Kaufmann, B. C., Pastore-Wapp, M., Bohlhalter, S., & Nyffeler, T. (2019). cTBS over contralesional homologue areas deteriorates speech output in isolated apraxia of speech after stroke. Brain Stimulation, 4, 1069–1071. https://doi.org/10.1016/j.brs.2019.03.024
- Cazzoli, D., Kaufmann, B. C., Pflugshaupt, T., Bohlhalter, S., & Nyffeler, T. (2018). The spatial distribution of perseverations in neglect patients during a nonverbal fluency task depends on the integrity of the right putamen. Neuropsychologia, 42–50. https://doi.org/10.1016/j.neuropsychologia.2018.01.025
Projects
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VERA - unravelling vertical visuospatial attention to enhance post-stroke recovery
Beim Überqueren einer Strasse blicken wir intuitiv nach links und rechts, prüfen die Ampel über uns und achten auf die Bordsteinkante unter unseren Füssen. Diese scheinbar selbstverständlichen Handlungen beruhen unter anderem auf komplexen Prozessen der visuell-räumlichen Aufmerksamkeit – eine Fähigkeit, die durch einen Schlaganfall erheblich beeinträchtigt werden kann. Ein Schlaganfall in der rechten Hirnhälfte führt häufig zu einem sogenannten Neglect, einer Vernachlässigung der linken Raumhälfte. Betroffene nehmen Objekte, Personen oder Ereignisse auf der linken Seite nicht wahr. Die Folgen im Alltag sind gravierend: Patientinnen und Patienten kollidieren mit Hindernissen, haben Schwierigkeiten unter anderem beim Navigieren oder Lesen. Während die horizontale Dimension (links/rechts) des Neglects bereits gut beschrieben ist, blieb die vertikale Dimension (oben/unten) bislang deutlich weniger erforscht. Dabei spielt auch sie im Alltag eine zentrale Rolle – etwa beim Erkennen von Ampeln, beim Absuchen von Regalen oder beim Treppensteigen. Das nun vom SNF geförderte Projekt «VERA Unravelling Vertical Visuospatial Attention to Enhance Post-Stroke Recovery» setzt auf Augenbewegungsanalysen, Magnetresonanztomographie und nicht-invasive Hirnstimulation. Dies, um die vertikale Dimension des Neglects sowie die zugrunde liegenden Hirnstrukturen besser zu verstehen. Im Zentrum steht zunächst die systematische Untersuchung des vertikalen Neglects nach einem Schlaganfall. Darauf aufbauend werden die neuroanatomischen Grundlagen erforscht, um zu klären, wie das Gehirn die Aufmerksamkeit nach oben oder unten lenkt. Abschliessend sollen jene neuronalen Netzwerke identifiziert werden, welche die Rehabilitation des vertikalen Neglects unterstützen. Die Erkenntnisse aus dem Projekt sollen längerfristig dabei helfen, diagnostische und therapeutische Ansätze für die Neglect-Patientinnen und -Patienten zu individualisieren und zu verbessern. Die Erkenntnisse aus dem Projekt sollen längerfristig dabei helfen, diagnostische und therapeutische Ansätze für die Neglect-Patientinnen und -Patienten zu individualisieren und zu verbessern. 2026– -
Cognitive Flexibility in Comparison: Do Modality and Individual Differences Influence Performance?
2025–